Edgar Allen Poe died under mysterious circumstances on October 7, 1849. There are a number of theories about his death, but it’s hard to know what really happened, because no autopsy was done. Here’s what a cardiologist from the University of Maryland concluded in 1996. If you have not visited the Poe House on Spring Garden, I highly recommend it. Read The Black Cat before visiting. That story is really brought to life in the basement.